Polyetheretherketone (PEEK) is considered one of the most innovative prosthetic materials of the last few decades. Its chemically inert behavior and high biocompatibility make it a promising material in many areas of dentistry. The aim of this study was to test whether PEEK with different TiO 2 filler contents achieves comparable bond strength values when using different resin cements. N = 70 PEEK samples each with different TiO 2 filler content (20 wt.% TiO 2 vs. 5 wt.% TiO 2 vs. no filler as a control group) were divided into seven groups and cemented with various conventional (ResiCem, RelyX Ultimate, Variolink Esthetic DC) and self-adhesive resin cements (RelyXUnicem 2, Bifix SE, Panavia SA Cement Plus, SpeedCem). The shear strength of the bond was assessed after 24 h and after 25,000 thermal loading cycles. Mann-Whitney U and Wilcoxon tests were used for statistical analysis (significance level: α = 0.05). PEEK without filler showed the highest mean shear strength (24.26 MPa using RelyX Ultimate), then high-filled PEEK (22.90 MPa using ResiCem) and low-filled PEEK (21.76 MPa using RelyX Ultimate). Conventional resin cements generally achieved slightly higher adhesive strengths than self-adhesive resin cements. It appears that the filler content does not affects the adhesive bond strengths.