nam 22 uu 4500 dbt_mods_00060146 10.3390/jcm13061522 doi dbt_mods_00060146 ger DE-601 rda eng 610 sdnb Iannaccone, Antonella Author aut Department of Obstetrics and Gynecology, University Hospital, University of Duisburg-Essen, 45147 Essen, Germany;(A.G.);(B.R.);(R.K.) The Importance of Vaccination, Variants and Time Point of SARS-CoV-2 Infection in Pregnancy for Stillbirth and Preterm Birth Risk: An Analysis of the CRONOS Register Study Iannaccone, Antonella;Gellhaus, Alexandra;Reisch, Beatrix;Dzietko, Mark;Schmidt, Boerge;Mavarani, Laven;Kraft, Katrina;Andresen, Kristin;Kimmig, Rainer;Pecks, Ulrich;Schleußner, Ekkehard;Cucinella, Gaspare 2024-03-07 10 Seiten text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Zweitveröffentlichung Background: The risk of preterm birth (PTB) and stillbirth increases after a SARS-CoV-2 infection during gestation. We aimed to estimate the risk depending on gestational age at infection (early <28 + 0 and late ≥28 weeks of gestation, WoG), virus variants, severity of infection, and vaccination. Methods: PTB was divided into early PTB (<32 + 0) and late PTB (32 + 0–36 + 6 WoG). The prospective register COVID-19 Related Obstetrics and Neonatal Outcome Study (CRONOS) included 8032 pregnant women with a confirmed SARS-CoV-2 infection from 3 April 2020 to 31 December 2022, in Germany and Austria. Results: Stillbirth and early preterm births rates were higher during the Alpha (1.56% and 3.13%) and Delta (1.56% and 3.44%) waves than during the Omicron wave (0.53% and 1.39%). Early SARS-CoV-2 infection increased the risk for stillbirth (aRR 5.76, 95% CI 3.07–10.83) and early PTB before 32 + 0 (aRR, 6.07, 95% CI 3.65–10.09). Hospital admission increased the risks further, especially in the case of ICU admission. Vaccination against SARS-CoV-2 significantly reduced the risk of stillbirth (aRR 0.32, 95% CI 0.16–0.83). Conclusions: This multicentric prospective study shows an increased risk of stillbirth and preterm birth after infection early in pregnancy and therefore the importance of obstetrical surveillance thereafter. Vaccination offers effective protection. vaccination preterm birth stillbirth COVID -19 SARS-CoV-2 alpha delta omicron wild-type article Gellhaus, Alexandra Author aut Department of Obstetrics and Gynecology, University Hospital, University of Duisburg-Essen, 45147 Essen, Germany;(A.G.);(B.R.);(R.K.) Reisch, Beatrix Author aut Department of Obstetrics and Gynecology, University Hospital, University of Duisburg-Essen, 45147 Essen, Germany;(A.G.);(B.R.);(R.K.) Dzietko, Mark Author aut Department of Pediatrics, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany; Schmidt, Boerge Author aut Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, 45147 Essen, Germany;(B.S.); Mavarani, Laven Author aut Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, 45147 Essen, Germany;(B.S.); Kraft, Katrina Author aut Department of Obstetrics and Gynecology, University Hospital of Lübeck, 23562 Lübeck, Germany; Andresen, Kristin Author aut Department of Obstetrics and Gynecology, University Hospital of Kiel, 24105 Kiel, Germany; Kimmig, Rainer Author aut Department of Obstetrics and Gynecology, University Hospital, University of Duisburg-Essen, 45147 Essen, Germany;(A.G.);(B.R.);(R.K.) Pecks, Ulrich Author aut Department of Obstetrics and Gynecology, University Hospital of Würzburg, 97080 Würzburg, Germany; Schleußner, Ekkehard Author aut Department of Obstetrics, Jena University Hospital, 07747 Jena, Germany; (DE-588)123039762 Cucinella, Gaspare Editor edt Friedrich-Schiller-Universität Jena Medizinische Fakultät host institution his 13:6:1522 Journal of Clinical Medicine 2077-0383 dbt_mods_00040909 https://www.db-thueringen.de/receive/dbt_mods_00060146 object in context https://www.db-thueringen.de/servlets/MCRFileNodeServlet/dbt_derivate_00062767/jcm-13-01522.pdf raw object https://www.db-thueringen.de/rsc/thumbnail/dbt_mods_00060146.png preview https://www.db-thueringen.de/receive/dbt_mods_00060146 uri