PT Journal
AU Ghafouri-Fard, S
   Ahmadi Teshnizi, S
   Hussen, BM
   Taheri, M
   Zali, H
TI A review on the role of GHET1 in different cancers
SO Pathology, research and practice
PD July
PY 2023
VL 247
PU Elsevier BV
DI 10.1016/j.prp.2023.154545
WP https://www.db-thueringen.de/receive/dbt_mods_00059877
LA en
DE Cell Line, Tumor; Humans; Neoplasms; Prognosis; Cell Cycle; Cell Proliferation; Cell Movement; Gene Expression Regulation, Neoplastic; Epithelial-Mesenchymal Transition; RNA, Long Noncoding; Biomarkers, Tumor; Cancer; Expression; Biomarker; Lncrna; Ghet1
AB Gastric cancer High Expressed Transcript 1 (GHET1) is an RNA gene located on chromosome 7q36.1. This non-coding RNA is involved in the pathology of different cancers. It can regulate cell proliferation, apoptosis and cell cycle transition. Moreover, it induces epithelial-mesenchymal transition. Up-regulation of GHET1 has been correlated with poor prognosis of patients with different malignancies. Besides, its up-regulation has been mostly detected in later stages and advanced grades of cancers. This review summarizes recent studies on the expression of GHET1, its in vitro functions, and its impact on the beginning and progression of cancer based on xenograft models of cancer.
PI München
ER