Analysis of human extracellular vesicles induced by Candida albicans

The opportunistic fungal pathogen Candida albicans can trigger bloodstream infection in immunocompromised and hospitalized patients with a high mortality rate. Upon infection with C. albicans or stimulation with yeast zymosan, human peripheral blood mononuclear cells substantially increase the release of extracellular vesicles. Secreted EVs provide a communication system between cells and regulate the immune response. A new mechanism of C. albicans immune evasion involves the formation and exploitation of host extracellular vesicles in response to fungi.