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A concise review on the role of MIR100HG in human disorders

ORCID
0000-0002-0223-499X
Affiliation
Department of Medical Genetics, School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran
Ghafouri‐Fard, Soudeh;
Affiliation
Phytochemistry Research Centre Shahid Beheshti University of Medical Sciences Tehran Iran
Harsij, Atefeh;
Affiliation
Phytochemistry Research Centre Shahid Beheshti University of Medical Sciences Tehran Iran
Farahzadi, Hossein;
Affiliation
Department of Clinical Analysis, College of Pharmacy Hawler Medical University Erbil Iraq
Hussen, Bashdar Mahmud;
GND
1249707153
Affiliation
Urology and Nephrology Research Centre Shahid Beheshti University of Medical Sciences Tehran Iran
Taheri, Mohammad;
Affiliation
Skull Base Research Centre, Loghman Hakim Hospital Shahid Beheshti University of Medical Sciences Tehran Iran
Mokhtari, Majid

Abstract MIR100HG is a long non‐coding RNA (lncRNA) encoded by a locus on chr11:122,028,203‐122,556,721. This gene can regulate cell proliferation, apoptosis, cell cycle transition and cell differentiation. MIR100HG was firstly identified through a transcriptome analysis and found to regulate differentiation of human neural stem cells. It is functionally related with a number of signalling pathways such as TGF‐β, Wnt, Hippo and ERK/MAPK signalling pathways. Dysregulation of MIR100HG has been detected in a diversity of cancers in association with clinical outcomes. Moreover, it has a role in the pathophysiology of dilated cardiomyopathy, intervertebral disk degeneration and pulmonary fibrosis. The current study summarizes the role of these lncRNAs in human disorders.

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Published in:
Journal of Cellular and Molecular Medicine
Vol. 27, No. 16 (18.07.2023), p. 2278-2289
Volume:
27
No.:
16
Date Issued:
18.07.2023
URN:
urn:nbn:de:gbv:27-dbt-20231011-000914-003
DOI:
10.1111/jcmm.17875
Language:
English
Type of Resource:
Text
Extent:
12 Seiten
Keywords:
  1. cancer
    Typ
    Schlagwort
  1. cardiomyopathy
    Typ
    Schlagwort
  1. fibrosis
    Typ
    Schlagwort
  1. lncRNA
    Typ
    Schlagwort
  1. MIR100HG
    Typ
    Schlagwort
DDC subject of DNB:
610 Medical sciences Medicine
Hosting institution:
Friedrich-Schiller-Universität Jena, Medizinische Fakultät
note:
Zweitveröffentlichung

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License Holder: © 2023 Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine

Use and reproduction:
This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.