nam 22 uu 4500 dbt_mods_00058808 10.1111/nph.19163 doi dbt_mods_00058808 ger DE-601 rda eng 580 sdnb Shiko, Glendis Author aut Department of Plant Physiology Matthias‐Schleiden‐Institute for Genetics, Bioinformatics and Molecular Botany, Friedrich Schiller University Jena Jena 07743 Germany (DE-588)1332675395 Occurrence and conversion of progestogens and androgens are conserved in land plants Shiko, Glendis;Paulmann, Max‐Jonas;Feistel, Felix;Ntefidou, Maria;Hermann‐Ene, Vanessa;Vetter, Walter;Kost, Benedikt;Kunert, Grit;Zedler, Julie A. Z.;Reichelt, Michael;Oelmüller, Ralf;Klein, Jan 2023-09-06 20 Seiten text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Zweitveröffentlichung Summary Progestogens and androgens have been found in many plants, but little is known about their biosynthesis and the evolution of steroidogenesis in these organisms. Here, we show that the occurrence and biosynthesis of progestogens and androgens are conserved across the viridiplantae lineage. An UHPLC‐ESI‐MS/MS method allowed high‐throughput analysis of the occurrence and chemical conversion of progestogens and androgens in 41 species across the green plant lineage. Dehydroepiandrosterone, testosterone, and 5α‐dihydrotestosterone are plants' most abundant mammalian‐like steroids. Progestogens are converted into 17α‐hydroxyprogesterone and 5α‐pregnane‐3,20‐dione. Androgens are converted into testosterone and 5α‐dihydrotestosterone. 17,20‐Lyases, essential for converting progestogens to androgens, seem to be most effective in monocot species. Our data suggest that the occurrence of progestogens and androgens is highly conserved in plants, and their biosynthesis might favor a route using the Δ 4 pathway. androgens Arabidopsis thaliana Chlamydomonas reinhardtii Hordeum vulgare Physcomitrium patens progestogens Spirodela polyrhiza steroidogenesis article Paulmann, Max‐Jonas Author aut Department of Plant Physiology Matthias‐Schleiden‐Institute for Genetics, Bioinformatics and Molecular Botany, Friedrich Schiller University Jena Jena 07743 Germany (DE-588)1332676871 Feistel, Felix Author aut Department for Biochemistry Max Planck Institute for Chemical Ecology 07743 Jena Germany Ntefidou, Maria Author aut Cell Biology, Department of Biology University Erlangen‐Nuremberg 91058 Erlangen Germany Hermann‐Ene, Vanessa Author aut Institute of Food Chemistry University of Hohenheim 70599 Stuttgart Germany Vetter, Walter Author aut Institute of Food Chemistry University of Hohenheim 70599 Stuttgart Germany Kost, Benedikt Author aut Cell Biology, Department of Biology University Erlangen‐Nuremberg 91058 Erlangen Germany Kunert, Grit Author aut Department for Biochemistry Max Planck Institute for Chemical Ecology 07743 Jena Germany Zedler, Julie A. Z. Author aut Synthetic Biology of Photosynthetic Organisms, Matthias Schleiden Institute for Genetics, Bioinformatics and Molecular Botany Friedrich Schiller University Jena 07743 Jena Germany (DE-588)1221641557 Reichelt, Michael Author aut Department for Biochemistry Max Planck Institute for Chemical Ecology 07743 Jena Germany Oelmüller, Ralf Author aut Department of Plant Physiology Matthias‐Schleiden‐Institute for Genetics, Bioinformatics and Molecular Botany, Friedrich Schiller University Jena Jena 07743 Germany (DE-588)1138200298 Klein, Jan Author aut Department of Plant Physiology Matthias‐Schleiden‐Institute for Genetics, Bioinformatics and Molecular Botany, Friedrich Schiller University Jena Jena 07743 Germany (DE-588)1230073647 Friedrich-Schiller-Universität Jena Fakultät für Biowissenschaften host institution his 240:1<318 Technische Universität Ilmenau, Universitätsbibliothek new phytologist 1469-8137 dbt_mods_00050306 1.1902 - https://www.db-thueringen.de/receive/dbt_mods_00058808 object in context https://www.db-thueringen.de/servlets/MCRFileNodeServlet/dbt_derivate_00061558/NPH_NPH19163.pdf raw object https://www.db-thueringen.de/rsc/thumbnail/dbt_mods_00058808.png preview https://www.db-thueringen.de/receive/dbt_mods_00058808 uri