000K  utf8
1100  2023$c2023-08-30
1500  eng
2050  urn:nbn:de:gbv:27-dbt-20230907-163151-004
2051  10.3390/pharmaceutics15092247
3000  Sprott, Haiko
3010  Fleck, Christian
4000  Hyaluronic Acid in Rheumatology  [Sprott, Haiko]
4060  18 Seiten
4209  Hyaluronic acid (HA), also known as hyaluronan, is an anionic glycosaminoglycan widely distributed throughout various tissues of the human body. It stands out from other glycosaminoglycans as it lacks sulfation and can attain considerable size: the average human synovial HA molecule weighs about 7 million Dalton (Da), equivalent to roughly 20,000 disaccharide monomers; although some sources report a lower range of 3–4 million Da. In recent years, HA has garnered significant attention in the field of rheumatology due to its involvement in joint lubrication, cartilage maintenance, and modulation of inflammatory and/or immune responses. This review aims to provide a comprehensive overview of HA’s involvement in rheumatology, covering its physiology, pharmacology, therapeutic applications, and potential future directions for enhancing patient outcomes. Nevertheless, the use of HA therapy in rheumatology remains controversial with conflicting evidence regarding its efficacy and safety. In conclusion, HA represents a promising therapeutic option to improve joint function and alleviate inflammation and pain.
4950  https://doi.org/10.3390/pharmaceutics15092247$xR$3Volltext$534
4950  https://nbn-resolving.org/urn:nbn:de:gbv:27-dbt-20230907-163151-004$xR$3Volltext$534
4961  https://www.db-thueringen.de/receive/dbt_mods_00058570
5051  610
5550  cartilage
5550  combination therapies
5550  hyaluronic acid
5550  inflammation
5550  joint lubrication
5550  osteoarthritis
5550  patient outcomes
5550  rheumatoid arthritis
5550  rheumatology
5550  therapeutic applications