000K utf8 1100 2023$c2023-08-22 1500 eng 2050 urn:nbn:de:gbv:27-dbt-20230907-153650-005 2051 10.3390/cancers15174201 3000 Civantos, Francisco 3010 Bradley, Patrick J. 3010 Coca-Pelaz, Andrés 3010 De Bree, Remco 3010 Ferlito, Alfio 3010 Guntinas-Lichius, Orlando 3010 Helmen, Zachary M. 3010 Kowalski, Luiz P. 3010 López, Fernando 3010 Mäkitie, Antti A. 3010 Rinaldo, Alessandra 3010 Robbins, K. Thomas 3010 Rodrigo, Juan P. 3010 Takes, Robert P. 4000 Lymph Node Metastases from Non-Melanoma Skin Cancer of the Head and Neck † [Civantos, Francisco] 4060 21 Seiten 4209 Simple Summary Skin cancer, particularly non-melanoma skin cancer, is the most common malignancy in the world. There are both common and uncommon types that receive treatment every day. Despite their commonality, the management of each is not perfectly defined in the scientific literature. Many require surgical removal, but the management of regional metastasis (such as lymph nodes in the neck) may or may not require surgical removal, or even anything beyond observation. Further complicating matters, some may have microscopic regional metastases that cannot be detected with a physical exam or imaging. This article seeks to summarize the current literature on this topic and to offer specific insight on how to manage non-melanoma skin cancer that has migrated away from the primary site to the regional lymph nodes. Abstract Non-melanoma skin cancer (NMSC) represents the most common malignancy in the world, comprising exceedingly common lesions such as basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) and rare lesions such as Merkel cell carcinoma. Risk factors are widely recognized and include ultraviolet (UV) light exposure, radiation exposure, immunosuppression, and many others. As a whole, survival and functional outcomes are favorable, but each histopathological subtype of NMSC behaves differently. Treatment regimens for the primary site usually include wide surgical excision and neck dissection in cases of clinically involved metastatic lymph nodes. The elective management of draining nodal basins, however, is a contested topic. Nearly all subtypes, excluding BCC, have a significant risk of lymphatic metastases, and have been studied with regard to sentinel lymph node biopsy (SLNB) and elective neck dissection. To date, no studies have definitively established a true single standard of care, as exists for melanoma, for any of the NMSCs. As a result, the authors have sought to summarize the current literature and identify indications and management options for the management of the cervical lymphatics for each major subtype of NMSC. Further research remains critically necessary in order to develop complete treatment algorithms. 4950 https://doi.org/10.3390/cancers15174201$xR$3Volltext$534 4950 https://nbn-resolving.org/urn:nbn:de:gbv:27-dbt-20230907-153650-005$xR$3Volltext$534 4961 https://www.db-thueringen.de/receive/dbt_mods_00058558 5051 610 5550 eccrine cell carcinoma 5550 Merkel cell carcinoma 5550 neck dissection 5550 neck metastases 5550 non-melanoma skin cancer 5550 sentinel lymph node biopsy 5550 squamous cell carcinoma