000K  utf8
1100  2023$c2023-08-03
1500  eng
2051  10.3389/fnins.2023.1242448
3000  Wu, Xingxuan
3010  Li, Zheng
3010  Wang, Zhao-Qi
3010  Xu, Xingzhi
4000  The neurological and non-neurological roles of the primary microcephaly-associated protein ASPM  [Wu, Xingxuan]
4060  22 Seiten
4209  Primary microcephaly (MCPH), is a neurological disorder characterized by small brain size that results in numerous developmental problems, including intellectual disability, motor and speech delays, and seizures. Hitherto, over 30 MCPH causing genes ( MCPHs ) have been identified. Among these MCPHs , MCPH5 , which encodes abnormal spindle-like microcephaly-associated protein (ASPM), is the most frequently mutated gene. ASPM regulates mitotic events, cell proliferation, replication stress response, DNA repair, and tumorigenesis. Moreover, using a data mining approach, we have confirmed that high levels of expression of ASPM correlate with poor prognosis in several types of tumors. Here, we summarize the neurological and non-neurological functions of ASPM and provide insight into its implications for the diagnosis and treatment of MCPH and cancer.
4950  https://doi.org/10.3389/fnins.2023.1242448$xR$3Volltext$534
4961  https://www.db-thueringen.de/receive/dbt_mods_00058448
5051  570
5550  ASPM
5550  cancer
5550  MCPH5
5550  microcephaly
5550  neurogenesis
5550  small brain