000K  utf8
1100  2023$c2023-06-29
1500  eng
2050  urn:nbn:de:gbv:27-dbt-20230714-053755-009
2051  10.3389/fimmu.2023.1183212
3000  Andreas, Nico
3010  Geißler, Katharina
3010  Guntinas-Lichius, Orlando
3010  Kamradt, Thomas
3010  Priese, Juliane
4000  Age-related changes of the innate immune system of the palatine tonsil in a healthy cohort  [Andreas, Nico]
4060  10 Seiten
4209  Although tonsillectomy is performed frequently, the role of palatine tonsils in life long immune protection or tolerance is still debated and the consequences of their removal for the immune system are of general interest. We analysed the tonsillar myeloid compartment in healthy subjects across a wide range of age (64% male; age range: 3 - 85 years) and compared its composition to the peripheral blood. We could observe a strong accumulation of all granulocyte subsets in the aging tonsil, which was most pronounced for basophils and mast cells. On functional level, an increase of CD163 and CD206 expression among monocytes and an increase of neutrophils expressing the inhibitory FcγRIIb correlated with increasing age. While the age-related shift of the leukocyte composition towards monocytes in blood is not reflected in tonsils, the increasing immunoregulatory phenotype of tonsilar monocytes is potentially counteracting the phenomenon of inflammaging at higher age.
4950  https://doi.org/10.3389/fimmu.2023.1183212$xR$3Volltext$534
4950  https://nbn-resolving.org/urn:nbn:de:gbv:27-dbt-20230714-053755-009$xR$3Volltext$534
4961  https://www.db-thueringen.de/receive/dbt_mods_00057920
5051  610
5550  aging
5550  blood
5550  flow cytometry
5550  healthy palatine tonsil
5550  human
5550  immune system
5550  myeloid