000K  utf8
1100  2023$c2023-06-21
1500  eng
2050  urn:nbn:de:gbv:27-dbt-20230712-040233-000
2051  10.1002/ijch.202200063
3000  Silpe, Justin E.
3010  Duddy, Olivia P.
3010  Papenfort, Kai
4000  Microbial Communication via Pyrazine Signaling$dA New Class of Signaling Molecules Identified in Vibrio cholerae  [Silpe, Justin E.]
4060  11 Seiten
4209  Quorum sensing is a microbial signaling process that relies on the production, release, and response to extracellular signaling molecules called autoinducers. This Review covers quorum‐sensing systems controlled by a pyrazine‐type autoinducer, 3,5‐dimethyl‐pyrazin‐2‐ol (DPO). The systems we cover span the human pathogen Vibrio cholerae , where DPO regulates pathogenicity and biofilm formation, and phage VP882, where DPO controls lytic development and viral dissemination. In both cases, detection of DPO occurs via a dedicated receptor‐transcription factor called VqmA. In V. cholerae , DPO activates the production of the VqmR regulatory RNA, and in the phage, DPO triggers production of the small protein Qtip. We present our current understanding of DPO biosynthesis, ongoing efforts to resolve the mechanisms underlying DPO‐mediated signal transduction, and a forward‐facing perspective on the role of DPO in human health and undiscovered pyrazine‐based signals in biology, more broadly.
4950  https://doi.org/10.1002/ijch.202200063$xR$3Volltext$534
4950  https://nbn-resolving.org/urn:nbn:de:gbv:27-dbt-20230712-040233-000$xR$3Volltext$534
4961  https://www.db-thueringen.de/receive/dbt_mods_00057885
5051  540
5550  DPO
5550  Quorum sensing
5550  Vibrio cholerae
5550  VP882
5550  VqmA