In contemporary theories of embodiment, resonance is used frequently to emphasize the complex interdependencies between body, mind and environment. A closer look at scientific, philosophical, and aesthetic theory of the enlightenment shows that resonance as a metaphor and figure of thought, describing increasingly complex phenomena of interaction and interdependencies, was already popular in cognitive theory (Hartley), psychology (Sulzer), psychiatry (Reil) and aesthetic theory (Webb, Schiller, Kant) in the 18th Century. In Germany, the concept of resonance becomes highly productive around 1800 when it is combined with “Stimmung” (tuning) as its precondition. The paper traces epistemologically significant transformations of the two closely linked figures within holistic anthropologies, challenging dualistic notions of body and mind since the enlightenment. After an overview of these figures during the Enlightenment, it concentrates on Jacob von Uexküll’s use of “Stimmung” in his physiological explanation of Kant’s teleological causality of living organisms in the middle of the 20th Century, which paves the way for their introduction into contemporary theories of embodiment and enactivism. The epistemological potential of these figures is illustrated in an analysis of Thomas Fuchs’ phenomenological theory of embodied anthropology, distinguishing clearly between a mechanical view of the body and the embodied experience of living organisms.