000K utf8 1100 2020$c2020-06 1500 eng 2050 urn:nbn:de:gbv:27-dbt-20230514-235639-008 2051 10.1007/s00270-020-02452-2 3000 Mietz, Selma 3010 Lehmann, Thomas 3010 Teichgräber, Ulf 4000 Multivariable Regression Analysis of Clinical Data from the Randomized-Controlled EffPac Trial: Efficacy of Femoropopliteal Drug-Coated Balloon Angioplasty [Mietz, Selma] 4060 10 Seiten 4209 Abstract Purpose The post-hoc multivariable analysis of EffPac study data aimed to identify explanatory variables for efficacy of femoropopliteal artery angioplasty. Methods In the prospective, randomized, controlled EffPac study, patients were allocated to either DCB or plain old balloon angioplasty. Multivariable regression including interaction analysis was conducted to assess the impact of selected variables on the outcome measures of late lumen loss (LLL) at 6 months, and on binary restenosis, target lesion revascularization (TLR), clinical improvement, and hemodynamic improvement at 12 months. Results A total of 171 patients (69 ± 8 years, 111 men) were treated at 11 German centers. Hypertension increased, and advanced age decreased LLL ( B coefficient [ B ]: 0.7 [95% CI − 0.04 to 1.3], p  = 0.06 and − 0.3 per 10 years [95% CI − 0.5 to 0.01], p  = 0.06, respectively). DCB angioplasty decreased odds of 12-month TLR and binary restenosis (OR 0.4 [95% CI 0.2 to 0.8], p  = 0.01 and OR 0.1 [95% CI 0.01 to 0.6], p  = 0.02, respectively). Lesion length and severe calcification decreased clinical improvement ( B : − 0.1 per 10 mm [95% CI − 0.1 to − 0.03], p  = 0.001 and − 0.1 [95% CI − 1.7 to − 0.1], p  = 0.03, respectively). DCB angioplasty in former smokers improved ABI (0.2 [95% CI 0.01 to 0.5], p  = 0.04). Conclusion DCB angioplasty decreased the incidence of 12-month restenosis and TLR. Increasing lesion length and severe calcification reduced clinical improvement. Hypertension is suspected to facilitate, and advanced age to mitigate LLL. DCB improved ABI most in former smokers. 4950 https://doi.org/10.1007/s00270-020-02452-2$xR$3Volltext$534 4950 https://nbn-resolving.org/urn:nbn:de:gbv:27-dbt-20230514-235639-008$xR$3Volltext$534 4961 https://www.db-thueringen.de/receive/dbt_mods_00057122 5051 610 5550 Drug-coated balloon angioplasty 5550 Femoropopliteal lesions 5550 Hypertension 5550 Regression analysis