https://www.db-thueringen.de/receive/dbt_mods_00057117https://www.db-thueringen.de/servlets/MCRFileNodeServlet/dbt_derivate_00060058/s00392-020-01722-w.pdfhttps://www.db-thueringen.de/rsc/thumbnail/dbt_mods_00057117.png text article COVID-19 among heart transplant recipients in Germany: a multicenter survey Rivinius, Rasmus Rivinius Rasmus German Center for Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim, Heidelberg, Germany aut Author Kaya, Ziya Kaya Ziya German Center for Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim, Heidelberg, Germany aut Author Schramm, René Schramm René Department of Thoracic and Cardiovascular Surgery, Heart and Diabetes Center NRW, Bad Oeynhausen, Germany aut Author Boeken, Udo Boeken Udo Department of Cardiac Surgery, Düsseldorf University Hospital, Düsseldorf, Germany aut Author article Provaznik, Zdenek Provaznik Zdenek Department of Cardiovascular Surgery, Regensburg University Hospital, Regensburg, Germany aut Author Heim, Christian Heim Christian Department of Cardiovascular Surgery, Erlangen University Hospital, Erlangen, Germany aut Author Knosalla, Christoph Knosalla Christoph German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany aut Author Schoenrath, Felix Schoenrath Felix German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Berlin, Germany aut Author Rieth, Andreas Rieth Andreas Department of Cardiology, Kerckhoff Hospital, Bad Nauheim, Germany aut Author Berchtold-Herz, Michael Berchtold-Herz Michael Department of Cardiovascular Surgery, University Heart Center Freiburg-Bad Krozingen, Freiburg, Germany aut Author Barten, Markus J. Barten Markus J. Department of Cardiovascular Surgery, University Heart and Vascular Center, Hamburg, Germany aut Author Rauschning, Dominic Rauschning Dominic Department of Internal Medicine, Bundeswehr Central Hospital, Koblenz, Germany aut Author urn:nbn:de:gbv:27-dbt-20230514-232021-001 Mücke, Victoria T. Mücke Victoria T. Department of Internal Medicine I, Frankfurt University Hospital, Frankfurt, Germany aut Author Heyl, Stephan Heyl Stephan Department of Internal Medicine III, Frankfurt University Hospital, Frankfurt, Germany aut Author Pistulli, Rudin Pistulli Rudin Department of Cardiology I - Coronary and Peripheral Vascular Disease, Heart Failure, Münster University Hospital, Münster, Germany aut Author Grinninger, Carola Grinninger Carola German Center for Cardiovascular Research (DZHK), Partner Site Munich, Munich, Germany aut Author Hagl, Christian Hagl Christian German Center for Cardiovascular Research (DZHK), Partner Site Munich, Munich, Germany aut Author Gummert, Jan F. Gummert Jan F. Department of Thoracic and Cardiovascular Surgery, Heart and Diabetes Center NRW, Bad Oeynhausen, Germany aut Author Warnecke, Gregor Warnecke Gregor Department of Cardiac Surgery, Heidelberg University Hospital, Heidelberg, Germany aut Author Schulze, P. Christian Schulze P. Christian Department of Cardiology, Angiology and Pneumology, Jena University Hospital, Jena, Germany aut Author 121635244 Katus, Hugo A. Katus Hugo A. German Center for Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim, Heidelberg, Germany aut Author Kreusser, Michael M. Kreusser Michael M. German Center for Infection Research (DZIF), Partner Site Heidelberg, Heidelberg, Germany aut Author Raake, Philip W. Raake Philip W. German Center for Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim, Heidelberg, Germany aut Author 10.1007/s00392-020-01722-w 2020-12 109 12 1531 1539 continuingjournal journal Clinical Research in Cardiology 1861-0684 1861-0692 Springer 2006 Berlin text en 610 Abstract Aims Heart transplantation may represent a particular risk factor for severe coronavirus infectious disease 2019 (COVID-19) due to chronic immunosuppression and frequent comorbidities. We conducted a nation-wide survey of all heart transplant centers in Germany presenting the clinical characteristics of heart transplant recipients with COVID-19 during the first months of the pandemic in Germany. Methods and results A multicenter survey of all heart transplant centers in Germany evaluating the current status of COVID-19 among adult heart transplant recipients was performed. A total of 21 heart transplant patients with COVID-19 was reported to the transplant centers during the first months of the pandemic in Germany. Mean patient age was 58.6 ± 12.3 years and 81.0% were male. Comorbidities included arterial hypertension (71.4%), dyslipidemia (71.4%), diabetes mellitus (33.3%), chronic kidney failure requiring dialysis (28.6%) and chronic-obstructive lung disease/asthma (19.0%). Most patients received an immunosuppressive drug regimen consisting of a calcineurin inhibitor (71.4%), mycophenolate mofetil (85.7%) and steroids (71.4%). Eight of 21 patients (38.1%) displayed a severe course needing invasive mechanical ventilation. Those patients showed a high mortality (87.5%) which was associated with right ventricular dysfunction (62.5% vs. 7.7%; p  = 0.014), arrhythmias (50.0% vs. none; p  = 0.012), and thromboembolic events (50.0% vs. none; p  = 0.012). Elevated high-sensitivity cardiac troponin T- and N-terminal prohormone of brain natriuretic peptide were significantly associated with the severe form of COVID-19 ( p  = 0.017 and p  < 0.001, respectively). Conclusion Severe course of COVID-19 was frequent in heart transplanted patients. High mortality was associated with right ventricular dysfunction, arrhythmias, thromboembolic events, and markedly elevated cardiac biomarkers. COVID-19 Heart transplantation Immunosuppression Mortality en 9 Seiten 610 his Host institution Zweitveröffentlichung dbt_mods_00057117https://www.db-thueringen.de/receive/dbt_mods_00057117