000K  utf8
1100  2022$c2022-12-05
1500  eng
2050  urn:nbn:de:gbv:27-dbt-20230419-225541-000
2051  10.1002/macp.202200241
3000  Würfel, Hendryk
3010  Anufriev, Ilya
3010  Geitel, Katja
3010  Günther, Wolfgang
3010  Heinze, Thomas
3010  Nischang, Ivo
3010  Schubert, Ulrich S.
4000  Glucose Scavenging with Pectin Hydrazide$dA Step toward Designing Innovative, Functional, All‐Sugar‐Based Polymers  [Würfel, Hendryk]
4060  7 Seiten
4209  Polygalacturonic acid hydrazide (PGH) is one of only a few polysaccharide derivatives with pronounced nucleophilic characteristics known today. This water‐soluble and benign material could be reacted with the hydrophilic aldehydes D ‐glucose in water, without any catalyst and at room temperature, resulting in a product that is the first example of new family of all‐sugar‐based polysaccharide derivatives. The reaction is reversible, allowing for D ‐glucose loading and unloading of the PGH. The D ‐glucose binds as the α −, and β anomer of the glucopyranosyl form. The reaction is orthogonal to the reactivity of the hydroxyl groups in the polysaccharide and enables the mild generation of new bio‐inspired polysaccharide derivatives. The glucose attachment could be rendered irreversibly by reducing the hydrazone with sodium cyanoborohydride, leading to the acyclic sugar derivative. A brief hydrodynamic and light scattering study of the polymers showed varying macromolecular properties at consistent molar mass values of the modified polysaccharide derivatives.
4950  https://doi.org/10.1002/macp.202200241$xR$3Volltext$534
4950  https://nbn-resolving.org/urn:nbn:de:gbv:27-dbt-20230419-225541-000$xR$3Volltext$534
4961  https://www.db-thueringen.de/receive/dbt_mods_00056915
5051  540
5550  glucose
5550  glycoconjugation
5550  glycosylhydrazides
5550  hydrazides
5550  pectin
5550  polygalacturonic acid, reversibility