Obesity during Pregnancy and SARS-CoV-2/COVID-19-Case Series of the Registry Study “COVID-19 Related Obstetric and Neonatal Outcome Study” (CRONOS-Network)

GND
1027071457
ORCID
0000-0002-2903-391X
Affiliation
Department of Obstetrics, University Hospital Jena, 07747 Jena, Germany
Weschenfelder, Friederike;
GND
1174819340
ORCID
0000-0002-1008-3714
Affiliation
Department of Obstetrics, University Hospital Jena, 07747 Jena, Germany
Zöllkau, Janine;
Affiliation
Department of Obstetrics and Gynecology, Berlin Center for Diabetes and Pregnancy, St. Joseph Hospital, 12101 Berlin, Germany
Schohe, Anna;
ORCID
0000-0002-0784-1262
Affiliation
Department of Obstetrics and Gynecology, University Hospital of Schleswig-Holstein, 24105 Kiel, Germany
Pecks, Ulrich;
GND
11819187X
ORCID
0000-0003-3553-4056
Affiliation
Department of Obstetrics, University Hospital Jena, 07747 Jena, Germany
Groten, Tanja;
Affiliation
Department of Obstetrics and Gynecology, Berlin Center for Diabetes and Pregnancy, St. Joseph Hospital, 12101 Berlin, Germany
Schaefer-Graf, Ute

(1) Background: Obesity is an increasing challenge in the care of pregnant women. The aim of our study was to investigate whether obesity is an independent risk factor for severe maternal and neonatal outcomes in pregnant women with COVID-19. (2) Methods: Data from the COVID-19 Related Obstetric and Neonatal Outcome Study (CRONOS), a prospective multicenter registry for SARS-CoV-2 positive pregnant women, was used to analyze the effect of obesity on selected individual and combined outcome parameters (3) Results: With 20.1%, the prevalence of obesity in the CRONOS registry exceeds the German background rate of 17.5%. Obese women showed significantly higher rates of GDM (20.4% vs. 7.6%; p < 0.001), hypertensive pregnancy disorders (6.2% vs. 2%; p = 0.004) and C-sections (50% vs. 34.5%; p < 0.001). BMI was revealed to be an individual risk factor for the severe combined pregnancy outcome (maternal death, stillbirth or preterm birth < 32 weeks) (OR 1.050, CI 1.005–1.097). (4) Conclusions: Maternal BMI is a predictor for the most severe outcome as maternal or neonatal death and preterm delivery <32 weeks of gestation. Unexpectedly, categorized obesity seems to have limited independent influence on the course and outcome of pregnancies with COVID infections.

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