https://www.db-thueringen.de/receive/dbt_mods_00056757https://www.db-thueringen.de/servlets/MCRFileNodeServlet/dbt_derivate_00059733/diagnostics-13-01144-v2.pdfhttps://www.db-thueringen.de/rsc/thumbnail/dbt_mods_00056757.png text article Liver PET Reloaded: Automated Synthesis of [ 68 Ga]Ga-BP-IDA for Positron Imaging of the Hepatobiliary Function and First Clinical Experience article Werner, Anke Werner Anke aut Author 116055045X Freesmeyer, Martin Freesmeyer Martin aut Author 0000-0002-6462-3851 12118918X Kühnel, Christian Kühnel Christian aut Author 0000-0003-3307-1772 1218326271 Drescher, Robert Drescher Robert aut Author 124886361 urn:nbn:de:gbv:27-dbt-20230405-150225-003 Greiser, Julia Greiser Julia aut Author 1195715986 10.3390/diagnostics13061144 2023-03-16 13 6 text continuingjournal Diagnostics open access journal journal 2011 Basel MDPI 2022-02-08 en 610 2075-4418 http://uri.gbv.de/document/gvk:ppn:718627814 2662336-5 his Host institution 1.2011 - Hepatobiliary scintigraphy is a well-established nuclear imaging method for evaluating liver function and displaying the biliary system, but the spatial and temporal resolution is limited, and, there is still no established PET equivalent. Adapted from the work of Schuhmacher et al. in 1983, the production of a 68 Gallium-labeled substitute, tetrabromophthalein ([ 68 Ga]Ga-BP-IDA), was undertaken according to current Good Manufacturing Practice (GMP) standards and proved feasible and reproducible. PET/CT with the radiotracer was performed in two complex patients with hepatocellular carcinoma in preparation for transarterial radioembolization. Due to its high spatial and temporal resolution, localization of areas with impaired liver function and visualization of the biliary system were possible. We could demonstrate that this 68 Gallium-labeled, IDA-based PET tracer is feasible and could advance hepatic and biliary function PET imaging. PET/CT hepatobiliary imaging liver function IDA derivatives dynamic PET HCC en 610 his Host institution dbt_mods_00056757https://www.db-thueringen.de/receive/dbt_mods_00056757