nam 22 uu 4500 dbt_mods_00056754 10.3390/cancers15061780 doi dbt_mods_00056754 ger DE-601 rda eng 610 sdnb Kouka, Mussab Author aut Department of Otorhinolaryngology, Jena University Hospital, 07747 Jena, Germany (DE-588)1275151620 The Association between Patient’s Age and Head and Neck Cancer Treatment Decision—A Population-Based Diagnoses-Related Group-Based Nationwide Study in Germany Kouka, Mussab;Hermanns, Isabel;Schlattmann, Peter;Guntinas-Lichius, Orlando 2023-03-15 14 Seiten text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Simple Summary The impact of the patient’s age on head and neck cancer (HNC) treatment decision has rarely been studied worldwide. Older age cohorts account for a high proportion of HNC patients and might influence the inpatient treatment decision (surgery, radiotherapy, chemotherapy/biologicals). This population-based study in Germany between 2005 and 2018 included data of 1,226,357 HNC cases. Negative binomial regression was performed to study the time-trend analysis on treatment decision. Older age cohorts (≥65 to <80 years and ≥80 years) predominantly have led to an increase in the treatment rates (biopsy, surgery, radiotherapy, chemotherapy/biologicals), younger ones (≥35 to <50 years and ≥50 to <65 years) to a decrease. Abstract Investigations on the association between patient’s age and head and neck cancer (HNC) treatment decision are sparse. Nationwide diagnoses-related group-based data of 1,226,357 cases hospitalized with primary HNC in Germany from 2005 to 2018 were included. Negative binomial regression was performed to study the development of the treatment rates over time. For all treatment options, i.e., biopsies, surgery, radiotherapy, and chemotherapy/biologicals, increases in the treatment rates were seen in patients >80 years (surgery: oral cavity: relative risk [RR]: 1.2, CI: 1.13–1.20; oropharynx: RR: 1.2, CI: 1.15–1.34; hypopharynx: RR: 1.1, CI: 1.02–1.17; larynx: RR: 1.1, CI: 1.04–1.12; radiotherapy: oral cavity: RR: 1.1, CI: 1.07–1.23; oropharynx: RR: 1.3, CI: 1.16–1.49; hypopharynx: RR: 1.3, CI: 1.21–1.46; larynx: RR 1.2, CI: 1.03–1.29; chemotherapy: oral cavity: RR: 1.2, CI: 1.06–1.31; salivary glands: RR: 1.3, CI: 1.09–1.50; oropharynx: RR: 1.4, CI: 1.12–1.83; hypopharynx: RR: 1.3, CI: 1.06–1.48; larynx: RR: 1.3, CI: 1.08–1.52, all p < 0.05). Older age cohorts (≥80 years) need more awareness as they are mainly responsible for the increase in the rates of surgery, radiotherapy, and chemotherapy/biologics in HNC patients. age diagnoses-related-group-based retrospective analysis treatment rate head and neck cancer article Hermanns, Isabel Author aut Department of Otorhinolaryngology, Jena University Hospital, 07747 Jena, Germany (DE-588)1286419816 Schlattmann, Peter Author aut Department of Medical Statistics, Computer Sciences and Data Sciences, Jena University Hospital, 07743 Jena, Germany (DE-588)138812187 Guntinas-Lichius, Orlando Author aut Department of Otorhinolaryngology, Jena University Hospital, 07747 Jena, Germany (DE-588)1078441464 Friedrich-Schiller-Universität Jena Medizinische Fakultät host institution his 15:6 Cancers (Basel) Cancers 2072-6694 dbt_mods_00040931 https://www.db-thueringen.de/receive/dbt_mods_00056754 object in context https://www.db-thueringen.de/servlets/MCRFileNodeServlet/dbt_derivate_00059730/cancers-15-01780-v2.pdf raw object https://www.db-thueringen.de/rsc/thumbnail/dbt_mods_00056754.png preview https://www.db-thueringen.de/receive/dbt_mods_00056754 uri