@Article{dbt_mods_00056513,
  author = 	{Coppin, Emilie
		and Sundarasetty, Bala Sai
		and Rahmig, Susann
		and Blume, Jonas
		and Verheyden, Nikita A.
		and Bahlmann, Franz
		and Ravens, Sarina
		and Schubert, Undine
		and Schmid, Janine
		and Ludwig, Stefan
		and Geissler, Katharina
		and Guntinas-Lichius, Orlando
		and von Kaisenberg, Constantin
		and Groten, Tanja
		and Platz, Alexander
		and Naumann, Ronald
		and Ludwig, Barbara
		and Prinz, Immo
		and Waskow, Claudia
		and Krueger, Andreas},
  title = 	{Enhanced differentiation of functional human T cells in NSGW41 mice with tissue-specific expression of human interleukin-7},
  journal = 	{Leukemia: normal and malignant hemopoiesis},
  year = 	{2021},
  month = 	{Dec},
  publisher = 	{Springer Nature},
  address = 	{London},
  volume = 	{35},
  number = 	{12},
  pages = 	{3561--3567},
  keywords = 	{Medicine/Public Health, general; Internal Medicine; Intensive / Critical Care Medicine; Cancer Research; Oncology; Hematology},
  abstract = 	{Humanized mouse models have become increasingly valuable tools to study human hematopoiesis and infectious diseases. However, human T-cell differentiation remains inefficient. We generated mice expressing human interleukin-7 (IL-7), a critical growth and survival factor for T cells, under the control of murine IL-7 regulatory elements. After transfer of human cord blood-derived hematopoietic stem and progenitor cells, transgenic mice on the NSGW41 background, termed NSGW41hIL7, showed elevated and prolonged human cellularity in the thymus while maintaining physiological ratios of thymocyte subsets. As a consequence, numbers of functional human T cells in the periphery were increased without evidence for pathological lymphoproliferation or aberrant expansion of effector or memory-like T cells. We conclude that the novel NSGW41hIL7 strain represents an optimized mouse model for humanization to better understand human T-cell differentiation in vivo and to generate a human immune system with a better approximation of human lymphocyte ratios.},
  note = 	{Zweitver{\"o}ffentlichung},
  issn = 	{0887-6924},
  doi = 	{10.1038/s41375-021-01259-5},
  url = 	{https://www.db-thueringen.de/receive/dbt_mods_00056513},
  url = 	{https://doi.org/10.1038/s41375-021-01259-5},
  file = 	{:https://www.db-thueringen.de/servlets/MCRFileNodeServlet/dbt_derivate_00059503/s41375-021-01259-5.pdf:PDF},
  language = 	{en}
}