Exosomal circular RNAs: New player in breast cancer progression and therapeutic targets

Affiliation
Department of Medical Analysis ,College of Pharmacy ,Hawler Medical University ,Erbil ,Iraq
Hussen, Bashdar Mahmud;
Affiliation
Department of Medical Analysis ,College of Pharmacy ,Hawler Medical University ,Erbil ,Iraq
Mohamadtahr, Sayran;
Affiliation
Medical Laboratory Science ,Lebanese French University ,Erbil ,Iraq
Abdullah, Snur Rasool;
Affiliation
Department of Biology ,College of Education ,Salahaddin University-Erbil ,Erbil ,Iraq
Hidayat, Hazha Jamal;
Affiliation
Department of Pharmaceutical Basic Science ,Faculty of Pharmacy ,Tishk International University ,Erbil ,Iraq
Rasul, Mohammad Fatih;
Affiliation
Department of Medical Laboratory Science ,Komar University of Science and Technology ,Sulaimany ,Iraq
Hama Faraj, Goran Sedeeq;
Affiliation
Department of Medical Genetics ,School of Medicine ,Shahid Beheshti University of Medical Sciences ,Tehran ,Iran
Ghafouri-Fard, Soudeh;
GND
1249707153
Affiliation
Institute of Human Genetics ,Jena University Hospital ,Jena ,Germany
Taheri, Mohammad;
Affiliation
Cancer Research Center ,Shahid Beheshti University of Medical Sciences ,Tehran ,Iran
Khayamzadeh, Maryam;
Affiliation
Department of Pathology ,Loghman Hakim Hospital ,Shahid Beheshti University of Medical Sciences ,Tehran ,Iran
Jamali, Elena

Breast cancer is the most prevalent type of malignancy among women. Exosomes are extracellular vesicles of cell membrane origin that are released via exocytosis. Their cargo contains lipids, proteins, DNA, and different forms of RNA, including circular RNAs. Circular RNAs are new class of non-coding RNAs with a closed-loop shape involved in several types of cancer, including breast cancer. Exosomes contained a lot of circRNAs which are called exosomal circRNAs. By interfering with several biological pathways, exosomal circRNAs can have either a proliferative or suppressive role in cancer. The involvement of exosomal circRNAs in breast cancer has been studied with consideration to tumor development and progression as well as its effects on therapeutic resistance. However, its exact mechanism is still unclear, and there have not been available clinical implications of exo-circRNAs in breast cancer. Here, we highlight the role of exosomal circRNAs in breast cancer progression and to highlight the most recent development and potential of circRNAas therapeutic targets and diagnostics for breast cancer.

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License Holder: Copyright © 2023 Hussen, Mohamadtahr, Abdullah, Hidayat, Rasul, Hama Faraj, Ghafouri-Fard, Taheri, Khayamzadeh and Jamali.

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