A Concise Review on Dysregulation of LINC00665 in Cancers

ORCID
0000-0002-0223-499X
Affiliation
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 19835-35511, Iran
Ghafouri-Fard, Soudeh;
Affiliation
Men’s Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran 16666-63111, Iran
Khoshbakht, Tayyebeh;
ORCID
0000-0003-1060-6527
Affiliation
Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil 44001, Iraq
Hussen, Bashdar Mahmud;
GND
112808337X
ORCID
0000-0003-1085-9161
Affiliation
Institute of Human Genetics, Jena University Hospital
Baniahmad, Aria;
GND
1249707153
ORCID
0000-0001-8381-0591
Affiliation
Institute of Human Genetics, Jena University Hospital
Taheri, Mohammad;
Affiliation
Critical Care Quality Improvement Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran 16666-63111, Iran
Hajiesmaeili, Mohammadreza

Long Intergenic Non-Protein Coding RNA 665 (LINC00665) is an RNA gene located on the minus strand of chromosome 19. This lncRNA acts as a competing endogenous RNA for miR-4458, miR-379-5p, miR-551b-5p, miR-3619-5p, miR-424-5p, miR-9-5p, miR-214-3p, miR-126-5p, miR-149-3p, miR-379-5p, miR-665, miR-34a-5p, miR-186-5p, miR-138-5p, miR-181c-5p, miR-98, miR-195-5p, miR-224-5p, miR-3619, miR-708, miR-101, miR-1224-5p, miR-34a-5p, and miR-142-5p. Via influencing expression of these miRNAs, it can enhance expression of a number of oncogenes. Moreover, LINC00665 can influence activity of Wnt/β-Catenin, TGF-β, MAPK1, NF-κB, ERK, and PI3K/AKT signaling. Function of this lncRNA has been assessed through gain-of-function tests and/or loss-of-function studies. Furthermore, diverse research groups have evaluated its expression levels in tissue samples using microarray and RT-qPCR techniques. In this manuscript, we have summarized the results of these studies and categorized them in three sections, i.e., cell line studies, animal studies, and investigations in clinical samples.

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