Therapeutic Potential of Microvesicles in Cell Therapy and Regenerative Medicine of Ocular Diseases With an Especial Focus on Mesenchymal Stem Cells-Derived Microvesicles

Affiliation
Department of Molecular and Cell Biology ,Faculty of Basic Sciences ,University of Mazandaran ,Babolsar ,Iran
Rad, Lina Moallemi;
Affiliation
Department of Prosthetic Dentistry ,Sechenov First Moscow State Medical University ,Moscow ,Russia
Yumashev, Alexey V.;
Affiliation
Department of Pharmacognosy ,College of Pharmacy ,Hawler Medical University ,Kurdistan Region ,Erbil ,Iraq
Hussen, Bashdar Mahmud;
Affiliation
Department of Biology ,College of Education ,Salahaddin University-Erbil ,Kurdistan Region ,Erbil ,Iraq
Jamad, Hazha Hadayat;
Affiliation
Department of Medical Genetics ,School of Medicine ,Shahid Beheshti University of Medical Sciences ,Tehran ,Iran
Ghafouri-Fard, Soudeh;
GND
1249707153
ORCID
0000-0001-8381-0591
Affiliation
Institute of Human Genetics ,Jena University Hospital
Taheri, Mohammad;
Affiliation
Department of Immunology ,School of Medicine ,Zanjan University of Medical Sciecnes ,Zanjan ,Iran
Rostami, Samaneh;
Affiliation
Department of Tissue Engineering and Applied Cell Sciences ,School of Advanced Technologies in Medicine ,Shahid Beheshti University of Medical Sciences ,Tehran ,Iran
Niazi, Vahid;
Affiliation
Skull Base Research Center ,Loghman Hakim Hospital ,Shahid Beheshti University of Medical Sciences ,Tehran ,Iran
Hajiesmaeili, Mohammadreza

These days, mesenchymal stem cells (MSCs), because of immunomodulatory and pro-angiogenic abilities, are known as inevitable factors in regenerative medicine and cell therapy in different diseases such as ocular disorder. Moreover, researchers have indicated that exosome possess an essential potential in the therapeutic application of ocular disease. MSC-derived exosome (MSC-DE) have been identified as efficient as MSCs for treatment of eye injuries due to their small size and rapid diffusion all over the eye. MSC-DEs easily transfer their ingredients such as miRNAs, proteins, and cytokines to the inner layer in the eye and increase the reconstruction of the injured area. Furthermore, MSC-DEs deliver their immunomodulatory cargos in inflamed sites and inhibit immune cell migration, resulting in improvement of autoimmune uveitis. Interestingly, therapeutic effects were shown only in animal models that received MSC-DE. In this review, we summarized the therapeutic potential of MSCs and MSC-DE in cell therapy and regenerative medicine of ocular diseases.

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License Holder: Copyright © 2022 Rad, Yumashev, Hussen, Jamad, Ghafouri-Fard, Taheri, Rostami, Niazi and Hajiesmaeili.

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