https://www.db-thueringen.de/receive/dbt_mods_00053867https://www.db-thueringen.de/servlets/MCRFileNodeServlet/dbt_derivate_00057644/cancers-14-04047-v3.pdfhttps://www.db-thueringen.de/rsc/thumbnail/dbt_mods_00053867.png text article Stereotactic Radiosurgery for Benign Cavernous Sinus Meningiomas: A Multicentre Study and Review of the Literature Santacroce, Antonio Santacroce Antonio Department of Neurosurgery, St. Barbara-Klinik Hamm-Heessen, 59073 Hamm, Germany Department of Medicine, Faculty of Health, Witten/Herdecke University, 58455 Witten, Germany aut Author 1150168021 Tuleasca, Constantin Tuleasca Constantin Neurosurgery Service and Gamma Knife Center, Lausanne University Hospital (CHUV), 1011 Lausanne, Switzerland Faculté de Biologie et de Médecine (FBM), Université de Lausanne (Unil), 1005 Lausanne, Switzerland Signal Processing Laboratory (LTS 5), Swiss Federal Institute of Technology (EPFL), 1015 Lausanne, Switzerland Faculté de Médecine, Sorbonné Université, 70513 Paris, France Assisstance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris Sud, Centre Hospitalier Universitaire Bicêtre, Service de Neurochirurgie, 94270 Le Kremlin-Bicêtre, France aut Author Liščák, Roman Liščák Roman Department of Stereotactic and Radiation Neurosurgery, Na Homolce Hospital, 15000 Prague, Czech Republic aut Author Motti, Enrico Motti Enrico Dipartimento di Neuroscienze, Neurochirurgia, Università degli Studi di Milano, 20122 Milano, Italy; Villa Maria Cecilia Hospital, 48033 Cotignola, Italy aut Author Lindquist, Christer Lindquist Christer Gamma Knife Centre, Bupa Cromwell Hospital, London SW5 0TU, UK aut Author Radatz, Matthias Radatz Matthias National Centre for Stereotactic Radiosurgery, Royal Hallamshire Hospital, Sheffield S10 2JF, UK aut Author Gatterbauer, Brigitte Gatterbauer Brigitte Department of Neurosurgery, Medical University of Vienna, 1090 Vienna, Austria aut Author article Lippitz, Bodo E. Lippitz Bodo E. Interdisciplinary Centre for Radiosurgery (ICERA), Radiological Alliance, 22767 Hamburg, Germany aut Author 0000-0001-5804-4549 Martínez Álvarez, Roberto Martínez Álvarez Roberto Department of Radiosurgery, Rúber International Hospital, 28034 Madrid, Spain aut Author Martínez Moreno, Nuria Martínez Moreno Nuria Department of Radiosurgery, Rúber International Hospital, 28034 Madrid, Spain aut Author 0000-0003-2400-704X Kamp, Marcel A. Kamp Marcel A. Department of Neurosurgery, Jena University Hospital, Friedrich-Schiller-University Jena, 07747 Jena, Germany aut Author 0000-0002-1252-2944 133492672 Sandvei Skeie, Bente Sandvei Skeie Bente Department of Neurosurgery, Haukeland University Hospital, 5021 Bergen, Norway aut Author 0000-0001-9876-5826 Schipmann, Stephanie Schipmann Stephanie Department of Neurosurgery, Haukeland University Hospital, 5021 Bergen, Norway aut Author Longhi, Michele Longhi Michele Unit of Radiosurgery and Stereotactic Neurosurgery, Department of Neurosciences, Azienda Ospedaliera Universitaria, 37126 Verona, Italy aut Author Unger, Frank Unger Frank Department of Neurosurgery, Medical University Graz, 8036 Graz, Austria aut Author Sabin, Ian Sabin Ian Gamma Knife Unit, Wellington Hospital (Platinum Medical Centre), London NW8 7JA, UK aut Author Mindermann, Thomas Mindermann Thomas Gamma Knife Center Zurich, Klinik Im Park Hirslanden, 8002 Zurich, Switzerland aut Author 0000-0002-8229-1926 urn:nbn:de:gbv:27-dbt-20221115-112327-005 Bundschuh, Otto Bundschuh Otto Gamma Knife Zentrum Hannover, 30167 Hannover, Germany aut Author Horstmann, Gerhard A. Horstmann Gerhard A. Gamma Knife Zentrum Krefeld, 47805 Krefeld, Germany aut Author van Eck, A.T.C. J. van Eck A.T.C. J. Gamma Knife Zentrum Krefeld, 47805 Krefeld, Germany aut Author Walier, Maja Walier Maja Institute of Medical Biometry, Epidemiology and Informatics, University Medical Center of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany Department of Mathematics and Technology, University of Applied Sciences Koblenz, Joseph-Rovan-Allee 2, 53424 Remagen, Germany aut Author Berres, Manfred Berres Manfred Institute of Medical Biometry, Epidemiology and Informatics, University Medical Center of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany Department of Mathematics and Technology, University of Applied Sciences Koblenz, Joseph-Rovan-Allee 2, 53424 Remagen, Germany aut Author Nakamura, Makoto Nakamura Makoto Department of Medicine, Faculty of Health, Witten/Herdecke University, 58455 Witten, Germany Department of Neurosurgery, Academic Hospital Köln-Merheim, 51058 Köln, Germany aut Author Steiger, Hans Jakob Steiger Hans Jakob Department of Neurosurgery, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany aut Author 0000-0002-8249-2998 Hänggi, Daniel Hänggi Daniel Department of Neurosurgery, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany aut Author Fortmann, Thomas Fortmann Thomas Department of Neurosurgery, St. Barbara-Klinik Hamm-Heessen, 59073 Hamm, Germany Department of Medicine, Faculty of Health, Witten/Herdecke University, 58455 Witten, Germany aut Author Alsofy, Samer Zawy Alsofy Samer Zawy Department of Neurosurgery, St. Barbara-Klinik Hamm-Heessen, 59073 Hamm, Germany Department of Medicine, Faculty of Health, Witten/Herdecke University, 58455 Witten, Germany aut Author 0000-0002-9592-3881 Régis, Jean Régis Jean Service de Neurochirurgie Fonctionnelle et Stereotaxique, Hôpital D’adulte de la Timone, 13354 Marseille, France aut Author 0000-0002-4842-3753 Ewelt, Christian Ewelt Christian Department of Neurosurgery, St. Barbara-Klinik Hamm-Heessen, 59073 Hamm, Germany Department of Neurosurgery, University Hospital Münster, Albert-Schweitzer-Campus 1, A1, 48149 Munster, Germany aut Author 131867881 W. McDermott, Michael W. McDermott Michael edt Editor 10.3390/cancers14164047 2022-08-22 14, 2022 16 4047 1 19 continuingjournal journal Cancers Cancers (Basel) 2072-6694 2527080-1 http://uri.gbv.de/document/gvk:ppn:614095670 MDPI 2009 Basel text en 610 Simple Summary Meningiomas are the most common tumours of the central nervous system (CNS). Despite their benign histology, proximity to critical neurovascular structures may lead to significant morbidity with tumour growth. This is the case for cavernous sinus meningiomas (CSMs), as their growth may surround critical neuro-vascular structures and cause significant morbidity. Radical microsurgical resection carries a high risk of additional neurological deficits, as well as the risk of death. Current management of these tumours, where treatment is indicated, has moved away from radical surgery towards radiotherapy/radiosurgery. This is particularly the case for patients who have residual or recurring tumours after previous surgery. There are many reports that describe the effectiveness of using stereotactic radiosurgery (SRS) for CSMs; however, large cohort analyses are lacking. This multicentre analysis reports the outcome data of over 1000 patients with CSMs who were treated with SRS. SRS shows a high local tumour control rate with few complications. These results agree with previous reports in the literature. SRS is a valuable primary or adjuvant treatment option for CSMs. Abstract Cavernous sinus meningiomas (CSMs) remain a surgical challenge due to the intimate involvement of their contained nerves and blood vessels. Stereotactic radiosurgery (SRS) is a safe and effective minimally invasive alternative for the treatment of small- to medium-sized CSMs. Objective: To assess the medium- to long-term outcomes of SRS for CSMs with respect to tumour growth, prevention of further neurological deterioration and improvement of existing neurological deficits. This multicentric study included data from 15 European institutions. We performed a retrospective observational analysis of 1222 consecutive patients harbouring 1272 benign CSMs. All were treated with Gamma Knife stereotactic radiosurgery (SRS). Clinical and imaging data were retrieved from each centre and entered into a common database. All tumours with imaging follow-up of less than 24 months were excluded. Detailed results from 945 meningiomas (86%) were then analysed. Clinical neurological outcomes were available for 1042 patients (85%). Median imaging follow-up was 67 months (mean 73.4, range 24–233). Median tumour volume was 6.2 cc (+/−7), and the median marginal dose was 14 Gy (+/−3). The post-treatment tumour volume decreased in 549 (58.1%), remained stable in 336 (35.6%) and increased in only 60 lesions (6.3%), yielding a local tumour control rate of 93.7%. Only 27 (2.8%) of the 60 enlarging tumours required further treatment. Five- and ten-year actuarial progression-free survival (PFS) rates were 96.7% and 90.1%, respectively. Tumour control rates were higher for women than men ( p = 0.0031), and also for solitary sporadic meningiomas ( p = 0.0201). There was no statistically significant difference in outcome for imaging-defined meningiomas when compared with histologically proven WHO Grade-I meningiomas ( p = 0.1212). Median clinical follow up was 61 months (mean 64, range 6–233). Permanent morbidity occurred in 5.9% of cases at last follow-up. Stereotactic radiosurgery is a safe and effective method for treating benign CSM in the medium term to long term. meningioma cavernous sinus stereotactic radiosurgery Gamma Knife multicentre study en 19 Seiten 610 his Host institution dbt_mods_00053867https://www.db-thueringen.de/receive/dbt_mods_00053867