Altered mannose metabolism in chronic stress and depression is rapidly reversed by vitamin B12

GND
1208739913
Affiliation
Institute of Human Genetics, University Hospital Jena, Friedrich Schiller University ,Jena ,Germany
Franzka, Patricia;
Affiliation
Department of Psychiatry, Douglas Mental Health University Institute, McGill University ,Montreal, QC ,Canada
Turecki, Gustavo;
GND
1290891435
Affiliation
Institute for Biochemistry and Biophysics, Friedrich-Schiller-University Jena ,Jena ,Germany
Cubillos, Susana;
Affiliation
Laboratory of Physiological Chemistry, de Duve Institute ,Brussels ,Belgium
Kentache, Takfarinas;
Affiliation
Clinic for Psychiatry and Psychotherapy, University Hospital of Otto-von-Guericke-Universität Magdeburg ,Magdeburg ,Germany
Steiner, Johann;
GND
1297477405
Affiliation
Department of Psychiatry and Psychotherapy, Jena University Hospital ,Jena ,Germany
Walter, Martin;
GND
140598111
Affiliation
Institute of Human Genetics, University Hospital Jena, Friedrich Schiller University ,Jena ,Germany
Hübner, Christian A.;
GND
1219859362
Affiliation
Institute of Human Genetics, University Hospital Jena, Friedrich Schiller University ,Jena ,Germany
Engmann, Olivia

GDP-Mannose Pyrophosphorylase B (GMPPB) is a key enzyme for glycosylation. Previous studies suggested a dysregulation of GMPBB and mannose in depression. Evidence, however, was sporadic and interventions to reverse these changes are unknown. Here, we show that GMPPB protein, but not RNA abundance is increased in the postmortem prefrontal cortex (PFC) of depressed patients and the chronic variable stress (CVS) mouse-model. This is accompanied by higher plasma mannose levels. Importantly, a single dose of intraperitoneally administered vitamin B12, which has previously been shown to rapidly reverse behavioral symptoms and molecular signatures of chronic stress in mice, normalized GMPPB plasma mannose levels and elevated GDP-mannose abundance. In summary, these data underline metabolic dysregulation in chronic stress and depression and provide further support for rapid effects of vitamin B12 on chronic stress.

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License Holder: Copyright © 2022 Franzka, Turecki, Cubillos, Kentache, Steiner, Walter, Hübner and Engmann.

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This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.