nam 22 uu 4500 dbt_mods_00053638 10.3390/jcm11185353 doi dbt_mods_00053638 ger DE-601 rda eng 610 sdnb Schönenberg, Aline Author aut Department of Geriatrics, Halle University Hospital, 06120 Halle, Germany Adherence to Medication in Neurogeriatric Patients Insights from the NeuroGerAd Study Schönenberg, Aline;Mühlhammer, Hannah M.;Lehmann, Thomas;Prell, Tino;Disanto, Giulio 2022-09-13 13 Seiten text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Zweitveröffentlichung Nonadherence to medication is associated with increased morbidity, mortality, and healthcare costs, especially in older adults with higher chances of multimorbidity. However, comprehensive data on factors influencing adherence in this patient group are rare. Thus, data for 910 patients were acquired, including demographic data, nonadherence (Stendal Adherence to Medication), depression (Beck Depression Inventory), cognition (Montreal Cognitive Assessment), personality (Big Five Inventory), satisfaction with healthcare (Health Care Climate Questionnaire), quality of life (36-item Short Form Survey), mobility, diagnoses, and medication. Elastic net regularization was used to analyze the predictors of adherence. Principal component and general estimation equations were calculated to analyze the underlying patterns of adherence. Only 21.1% of patients were fully adherent. Nonadherence was associated with male gender, higher number of medications, diagnosis, depression, poor patient–physician relationship, personality, impaired cognition, and impaired mobility. Nonadherence was classified into three sub-factors: forgetting (46.2%), missing knowledge about medication (29%), and intentional modification of medication (24.8%). While depression exerted the strongest influence on modification, a high number of medications was associated with missing knowledge. The different patterns of nonadherence (i.e., modification, missing knowledge, and forgetting) are influenced differently by clinical factors, indicating that specific approaches are needed for interventions targeting adherence. depression older adults medication adherence quality of life multimorbidity article Mühlhammer, Hannah M. Author aut Department of Neurology, Jena University Hospital, 07747 Jena, Germany (DE-588)1290798923 Lehmann, Thomas Author aut Institute for Medical Statistics, Computer and Data Sciences, Jena University Hospital, 07747 Jena, Germany (DE-588)1216191093 Prell, Tino Author aut Department of Neurology, Jena University Hospital, 07747 Jena, Germany Department of Neurology, Jena University Hospital, 07747 Jena, Germany (DE-588)137373155 Disanto, Giulio Editor edt Friedrich-Schiller-Universität Jena Medizinische Fakultät host institution his 11:18:5353<1 Journal of Clinical Medicine 2077-0383 dbt_mods_00040909 https://www.db-thueringen.de/receive/dbt_mods_00053638 object in context https://www.db-thueringen.de/servlets/MCRFileNodeServlet/dbt_derivate_00057444/jcm-11-05353.pdf raw object https://www.db-thueringen.de/rsc/thumbnail/dbt_mods_00053638.png preview https://www.db-thueringen.de/receive/dbt_mods_00053638 uri