Genetic Survey of Psilocybe Natural Products

GND
1279104821
Affiliation
Department Pharmaceutical Microbiology at the Hans-Knöll-Institute Friedrich-Schiller-Universität Beutenbergstrasse 11a 07745 Jena Germany
Dörner, Sebastian;
GND
129904817X
Affiliation
Department Pharmaceutical Microbiology at the Hans-Knöll-Institute Friedrich-Schiller-Universität Beutenbergstrasse 11a 07745 Jena Germany
Rogge, Kai;
GND
122262107X
ORCID
0000-0002-6443-3185
Affiliation
Department Pharmaceutical Microbiology at the Hans-Knöll-Institute Friedrich-Schiller-Universität Beutenbergstrasse 11a 07745 Jena Germany
Fricke, Janis;
GND
1299220282
Affiliation
Department Pharmaceutical Microbiology at the Hans-Knöll-Institute Friedrich-Schiller-Universität Beutenbergstrasse 11a 07745 Jena Germany
Schäfer, Tim;
GND
1299061818
Affiliation
Department Pharmaceutical Microbiology at the Hans-Knöll-Institute Friedrich-Schiller-Universität Beutenbergstrasse 11a 07745 Jena Germany
Wurlitzer, Jacob M.;
GND
1072725606
ORCID
0000-0001-5669-7618
Affiliation
Department Pharmaceutical Microbiology at the Hans-Knöll-Institute Friedrich-Schiller-Universität Beutenbergstrasse 11a 07745 Jena Germany
Gressler, Markus;
Affiliation
Department of Chemistry & Biochemistry University of Massachusetts 285 Old Westport Road Dartmouth MA 02747 USA
Pham, Duyen N. K.;
Affiliation
Department of Chemistry & Biochemistry University of Massachusetts 285 Old Westport Road Dartmouth MA 02747 USA
Manke, David R.;
Affiliation
CaaMTech, LLC 58 East Sunset Way Issaquah WA 98027 USA
Chadeayne, Andrew R.;
GND
124018092
ORCID
0000-0002-5302-6461
Affiliation
Department Pharmaceutical Microbiology at the Hans-Knöll-Institute Friedrich-Schiller-Universität Beutenbergstrasse 11a 07745 Jena Germany
Hoffmeister, Dirk

Psilocybe magic mushrooms are best known for their main natural product, psilocybin, and its dephosphorylated congener, the psychedelic metabolite psilocin. Beyond tryptamines, the secondary metabolome of these fungi is poorly understood. The genomes of five species ( P. azurescens , P. cubensis , P. cyanescens , P. mexicana , and P. serbica ) were browsed to understand more profoundly common and species‐specific metabolic capacities. The genomic analyses revealed a much greater and yet unexplored metabolic diversity than evident from parallel chemical analyses. P. cyanescens and P. mexicana were identified as aeruginascin producers. Lumichrome and verpacamide A were also detected as Psilocybe metabolites. The observations concerning the potential secondary metabolome of this fungal genus support pharmacological and toxicological efforts to find a rational basis for yet elusive phenomena, such as paralytic effects, attributed to consumption of some magic mushrooms.

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