The emerging role of long non-coding RNAs, microRNAs, and an accelerated epigenetic age in Huntington’s disease

Affiliation
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences ,Tehran ,Iran
Ghafouri-Fard, Soudeh;
Affiliation
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences ,Tehran ,Iran
Khoshbakht, Tayyebeh;
Affiliation
Department of Pharmacognosy, College of Pharmacy, Hawler Medical University ,Erbil ,Iraq
Hussen, Bashdar Mahmud;
GND
1249707153
Affiliation
Institute of Human Genetics, Jena University Hospital ,Jena ,Germany
Taheri, Mohammad;
Affiliation
Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences ,Tehran ,Iran
Ebrahimzadeh, Kaveh;
Affiliation
Malopolska Centre of Biotechnology, Jagiellonian University ,Krakow ,Poland
Noroozi, Rezvan

Huntington’s disease (HD) is a dominantly inherited neurodegenerative disease with variable clinical manifestations. Recent studies highlighted the contribution of epigenetic alterations to HD progress and onset. The potential crosstalk between different epigenetic layers and players such as aberrant expression of non-coding RNAs and methylation alterations has been found to affect the pathogenesis of HD or mediate the effects of trinucleotide expansion in its pathophysiology. Also, microRNAs have been assessed for their roles in the modulation of HD manifestations, among them are miR-124, miR-128a, hsa-miR-323b-3p, miR-432, miR-146a, miR-19a, miR-27a, miR-101, miR-9*, miR-22, miR-132, and miR-214. Moreover, long non-coding RNAs such as DNM3OS, NEAT1, Meg3, and Abhd11os are suggested to be involved in the pathogenesis of HD. An accelerated DNA methylation age is another epigenetic signature reported recently for HD. The current literature search collected recent findings of dysregulation of miRNAs or lncRNAs as well as methylation changes and epigenetic age in HD.

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License Holder: Copyright © 2022 Ghafouri-Fard, Khoshbakht, Hussen, Taheri, Ebrahimzadeh and Noroozi.

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