Placental damage in pregnancies with systemic lupus erythematosus: A narrative review

Affiliation
BCNatal, Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu), Institut Clínic de Ginecologia, Obstetrícia i Neonatologia Fetal i+D Fetal Medicine Research Center ,Barcelona ,Spain
Castellanos Gutierrez, Aleida Susana;
GND
1057036102
Affiliation
BCNatal, Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu), Institut Clínic de Ginecologia, Obstetrícia i Neonatologia Fetal i+D Fetal Medicine Research Center ,Barcelona ,Spain
Figueras, Francesc;
GND
1029632839
Affiliation
Placenta Lab, Department of Obstetrics, Jena University Hospital ,Jena ,Germany
Morales Prieto, Diana Maria;
GND
123039762
Affiliation
Placenta Lab, Department of Obstetrics, Jena University Hospital ,Jena ,Germany
Schleußner, Ekkehard;
Affiliation
Institut d’Investigacions Biomèdiques Pi i Sunyer (IDIBAPS) ,Barcelona ,Spain
Espinosa, Gerard;
Affiliation
BCNatal, Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clínic and Hospital Sant Joan de Déu), Institut Clínic de Ginecologia, Obstetrícia i Neonatologia Fetal i+D Fetal Medicine Research Center ,Barcelona ,Spain
Baños, Núria

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease of unknown cause, which mainly affects women of childbearing age, especially between 15 and 55 years of age. During pregnancy, SLE is associated with a high risk of perinatal morbidity and mortality. Among the most frequent complications are spontaneous abortion, fetal death, prematurity, intrauterine Fetal growth restriction (FGR), and preeclampsia (PE). The pathophysiology underlying obstetric mortality and morbidity in SLE is still under investigation, but several studies in recent years have suggested that placental dysfunction may play a crucial role. Understanding this association will contribute to developing therapeutic options and improving patient management thus reducing the occurrence of adverse pregnancy outcomes in this group of women. In this review, we will focus on the relationship between SLE and placental insufficiency leading to adverse pregnancy outcomes.

Cite

Citation style:
Could not load citation form.

Rights

License Holder: Copyright © 2022 Castellanos Gutierrez, Figueras, Morales-Prieto, Schleußner, Espinosa and Baños

Use and reproduction: