000K  utf8
1100  2022$c2022-04-27
1500  eng
2050  urn:nbn:de:gbv:27-dbt-20220706-080659-002
2051  10.3389/fimmu.2022.877243
3000  Ghafouri-Fard, Soudeh
3010  Dashti, Farzaneh
3010  Hussen, Bashdar
3010  Jamali, Elena
3010  Poornajaf, Yadollah
3010  Taheri, Mohammad
4000  Interaction Between Non-Coding RNAs and Interferons: With an Especial Focus on Type I Interferons$hFrontiers Media  [Ghafouri-Fard, Soudeh]
4030  Lausanne$nFrontiers Media
4060  12 Seiten
4209  Interferons (IFNs) are a group of cellular proteins with critical roles in the regulation of immune responses in the course of microbial infections. Moreover, expressions of IFNs are dysregulated in autoimmune disorders. IFNs are also a part of immune responses in malignant conditions. The expression of these proteins and activities of related signaling can be influenced by a number of non-coding RNAs. IFN regulatory factors (IRFs) are the most investigated molecules in the field of effects of non-coding RNAs on IFN signaling. These interactions have been best assessed in the context of cancer, revealing the importance of immune function in the pathoetiology of cancer. In addition, IFN-related non-coding RNAs may contribute to the pathogenesis of neuropsychiatric conditions, systemic sclerosis, Newcastle disease, Sjögren’s syndrome, traumatic brain injury, lupus nephritis, systemic lupus erythematosus, diabetes mellitus, and myocardial ischemia/reperfusion injury. In the current review, we describe the role of microRNAs and long non-coding RNAs in the regulation of IFN signaling.
4950  https://doi.org/10.3389/fimmu.2022.877243$xR$3Volltext$534
4950  https://nbn-resolving.org/urn:nbn:de:gbv:27-dbt-20220706-080659-002$xR$3Volltext$534
4961  https://www.db-thueringen.de/receive/dbt_mods_00052536
5051  610
5550  biomarker
5550  expression
5550  interferon
5550  lncRNA
5550  miRNA