Regulatory Role of Non-Coding RNAs on Immune Responses During Sepsis

Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences
Ghafouri-Fard, Soudeh;
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences
Khoshbakht, Tayyebeh;
Department of Pharmacognosy, College of Pharmacy, Hawler Medical University
Hussen, Bashdar Mahmud;
Institute of Human Genetics, Jena University Hospital
Taheri, Mohammad;
Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences
Arefian, Normohammad

Sepsis is resulted from a systemic inflammatory response to bacterial, viral, or fungal agents. The induced inflammatory response by these microorganisms can lead to multiple organ system failure with devastating consequences. Recent studies have shown altered expressions of several non-coding RNAs such as long non-coding RNAs (lncRNAs), microRNAs (miRNAs) and circular RNAs (circRNAs) during sepsis. These transcripts have also been found to participate in the pathogenesis of multiple organ system failure through different mechanisms. NEAT1, MALAT1, THRIL, XIST, MIAT and TUG1 are among lncRNAs that participate in the pathoetiology of sepsis-related complications. miR-21, miR-155, miR-15a-5p, miR-494-3p, miR-218, miR-122, miR-208a-5p, miR-328 and miR-218 are examples of miRNAs participating in these complications. Finally, tens of circRNAs such as circC3P1, hsa_circRNA_104484, hsa_circRNA_104670 and circVMA21 and circ-PRKCI have been found to affect pathogenesis of sepsis. In the current review, we describe the role of these three classes of noncoding RNAs in the pathoetiology of sepsis-related complications.


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License Holder: Copyright © 2021 Ghafouri-Fard, Khoshbakht, Hussen, Taheri and Arefian

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This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.