PT Unknown
AU Nothnagel, H
TI Methodische Herausforderungen der Messung chronischer Schmerzen bei der Durchführung klinischer Studien
PY 2021
WP https://www.db-thueringen.de/receive/dbt_mods_00050752
LA de
DE Chronischer Schmerze; Schmerzschwelle; Klinisches Experiment; Diagnose; Algesimetrie; Schmerzreiz; Empfindlichkeit
AB The development of pain and the transmission of pain stimuli via the nervous system (nociception) are complex processes that usually occur in the same way. In contrast, sensation as well as perception of pain are subjective and depend, among other factors, on gender-related, sociocultural, and social factors. While the focus is on finding the cause and targeted therapy in acute pain, the original cause is often no longer identifiable in chronic pain. The complexity of chronic pain is challenging both in clinical practice and in pain research. In addition, the subjectivity of pain perception complicates pain diagnostics, especially with regard to the measurement of pain intensity and pain sensitivity. The present thesis addresses the challenges of conducting clinical trials on chronic pain based on the complexity of chronic pain, its diagnosis and recording. Firstly, the current state of research on pain and chronic pain is presented. Based on this, three studies are presented that deal with method-critical aspects in the conduct of clinical studies on chronic pain. The results presented in this thesis are of high relevance and have broad significance for clinical studies of chronic pain. Recommendations are given which are applicable in clinical practice as well as in clinical research on chronic pain.
PI Jena
ER