Controlling effects of astrocyte on neuron behavior in tripartite synapse using vhdl–ams

ORCID
0000-0002-5806-3237
Affiliation
1 Department of Industrial Engineering, Faculty of Engineering, King Abdulaziz University, P.O. Box 80204, Jeddah 21589, Saudi Arabia; otaylan@kau.edu.sa (O.T.); fbano@kau.edu.sa (F.B.)
Taylan, Osman;
Affiliation
2 Department of Management and Information Systems, College of Business Administration, Taibah University, Medina 42353, Saudi Arabia; mabusurrah@taibahu.edu.sa
Abusurrah, Mona;
GND
1231322179
ORCID
0000-0003-1480-1450
Affiliation
3 Institute of Optics and Quantum Electronics, Friedrich Schiller University Jena, Max-Wien-Platz 1, 07743 Jena, Germany
Eftekhari-Zadeh, Ehsan;
ORCID
0000-0001-5457-6943
Affiliation
4 Imec-Vision Lab, Department of Physics, University of Antwerp, 2610 Antwerp, Belgium; ehsan.nazemi@uantwerpen.be
Nazemi, Ehsan;
ORCID
0000-0003-1873-9121
Affiliation
1 Department of Industrial Engineering, Faculty of Engineering, King Abdulaziz University, P.O. Box 80204, Jeddah 21589, Saudi Arabia; otaylan@kau.edu.sa (O.T.); fbano@kau.edu.sa (F.B.)
Bano, Farheen;
Affiliation
5 Computer Engineering Department, Kermanshah University of Technology, Kermanshah 6715685420, Iran; aliroshani@kut.ac.ir
Roshani, Ali

Astrocyte cells form the largest cell population in the brain and can influence neuron behavior. These cells provide appropriate feedback control in regulating neuronal activities in the Central Nervous System (CNS). This paper presents a set of equations as a model to describe the interactions between neurons and astrocyte. A VHDL–AMS-based tripartite synapse model that includes a pre-synaptic neuron, the synaptic terminal, a post-synaptic neuron, and an astrocyte cell is presented. In this model, the astrocyte acts as a controller module for neurons and can regulates the spiking activity of them. Simulation results show that by regulating the coupling coefficients of astrocytes, spiking frequency of neurons can be reduced and the activity of neuronal cells is modulated.

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This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.