Sand-bentonite mixtures are well recognized as buffer and sealing material in nuclear waste repository constructions. The behaviour of compacted sand-bentonite mixture needs to be well understood in order to guarantee the safety and the efficiency of the barrier construction. This paper presents numerical simulations of swelling test and coupled thermo-hydro-mechanical (THM) test on compacted sand-bentonite mixture in order to reveal the influence of the temperature and hydraulic gradients on the distribution of temperature, mechanical stress and water content in such materials. Sensitivity analysis is carried out to identify the parameters which influence the most the response of the numerical model. Results of back analysis of the model parameters are reported and critically assessed.