Bridge vibration due to traffic loading has been subject of extensive research in the last decades. Such studies are concerned with deriving solutions for the bridge-vehicle interaction (BVI) and analyzing the dynamic responses considering randomness of the coupled model’s (BVI) input parameters and randomness of road unevenness. This study goes further to examine the effects of such randomness of input parameters and processes on the variance of dynamic responses in quantitative measures. The input parameters examined in the sensitivity analysis are, stiffness and damping of vehicle’s suspension system, axle spacing, and stiffness and damping of bridge. This study also examines the effects of the initial excitation of a vehicle on the influences of the considered input parameters. Variance based sensitivity analysis is often applied to deterministic models. However, the models for the dynamic problem is a stochastic one due to the simulations of the random processes. Thus, a setting using a joint meta-model; one for the mean response and other for the dispersion of the response is developed. The joint model is developed within the framework of Generalized Linear Models (GLM). An enhancement of the GLM procedure is suggested and tested; this enhancement incorporates Moving Least Squares (MLS) approximation algorithms in the fitting of the mean component of the joint model. The sensitivity analysis is then performed on the joint-model developed for the dynamic responses caused by BVI.