@PhdThesis{dbt_mods_00022549,
  author = 	{Sch{\"u}tze Dr.rer.nat., Christina},
  title = 	{Synthese und Funktionalisierung von Fulleren C60 und seinen Derivaten f{\"u}r die Anwendung in biologischen Systemen},
  year = 	{2013},
  month = 	{Jul},
  day = 	{09},
  keywords = 	{Fullerene  Fluoreszenzfarbstoffe Biologische Untersuchungen},
  abstract = 	{The modification of C60 and its derivatives with polar side chains to
improve the solubility in polar and aqueous medium is of significant
importance for biological and medical applications. Although fullerene
derivatives have been used in numerous biological systems their interaction
mechanism with these structures is almost unknown. The functionalization of
fullerenes with fluorescent dyes should be able to contribute to the
elucidation of these mechanisms.For the functionalization reactions
different dyes have been selected, which are derived from either a
fluorescein or an aniline structure. These dyes functionalized with amino-
or isothiocyanate groups have been reacted with fullerocarboxylic acids or
acid chlorides as well as fulleropyrrolidines to form dye-functionalized
C60- and C70-derivatives. In preliminary studies with a model membrane the
dye-functionalized fullerene derivatives have shown unequal behavior and
interesting fluorescence properties. Allowing the attachment of dyes which
have no amino functions available, various synthetic routes for the
introduction of amino groups on the fullerene surface have been examined,
ranging from the reaction of amino-functionalized diazomethanes to the
attachment of glykoldiamines. The functionalization of fullerenes with
glykoldiamines is connected to the synthesis of fullerene derivatives which
show a significantly improved solubility in polar media or even water and
can also be functionalized with dyes. About this synthetic method a class
of compounds could be synthesized which has enormous potential for
biological and medical applications.},
  url = 	{https://www.db-thueringen.de/receive/dbt_mods_00022549},
  url = 	{http://uri.gbv.de/document/gvk:ppn:751417564},
  file = 	{:https://www.db-thueringen.de/servlets/MCRZipServlet/dbt_derivate_00027886:TYPE},
  language = 	{de}
}