Studies on the removal of human topoisomerase I cleavage complexes in vitro and the involvement of the tumor suppressor protein p53

Söe, Kent

In the present thesis the in vitro repair of a human topoisomerase I cleavage complex was investigated. It was found that a second human topoisomerase I molecule can recognize such a cleavage complex and that this is stimulated by the tumor suppressor protein p53. It was suggested that this may represent the first step in a repair of the human topoisomerase I cleavage complex through recombination.

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Söe, Kent: Studies on the removal of human topoisomerase I cleavage complexes in vitro and the involvement of the tumor suppressor protein p53. 2002.

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